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Fat browning refers to the high plasticity of white fat cells, which can be transformed into beige fat cells with many similar morphological and functional characteristics to brown fat cells under the stimulation of exercise, cold exposure, adrenergic receptor stimulation, and other factors [83]

Selective Agonism Rather than activating receptors fully, some experimental medications partially activate them or activate specific subtypes

Gastric inhibitory polypeptide (GIP) stimulated by fat ingestion in man

At 48 weeks, the liver fat reductions were even more pronounced, with approximately 90% of individuals receiving maximum dose levels achieving normalization of liver fat [25]

Both are self-administered as a small weekly injection

GLP-1s vary in benefit, cause side effects, and have high dropout