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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

Bacterial contamination at levels sufficient to compromise peptide stability produces no visible cloudiness, meaning clear solution appearance does not guarantee sterility

A sterile solution should have none

You can also experience discolouration in your nails and slow hair growth which can impede on your appearance

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