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et al., oral administration of Lactiplantibacillus plantarum Y15 to STZ + HFD-induced T2D mice improved fasting glucose, HbA1c, and HOMA-IR levels, reduced pro-inflammatory cytokines (IL-6, TNF-, among others), decreased the abundance of LPS-producing bacteria, and promoted SCFA-producing populations

Mitochondrial membrane potential assessment Mitochondrial membrane potential was determined using Tetrechloro-tetraethylbenzimidazol carbocyanine iodide (JC-1), following the protocols provided by the respective manufacturers (Beyotime, China)

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Thus, 15LO1 pathwayinduced redox biology perturbations worsen T2 inflammation and asthma control, supporting 15LO1 as a therapeutic target