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These Kupffer cell effects were also associated with hepatocellular damage in rats and Guinea pigs, however this finding was not observed in the Rhesus monkeys, suggesting that species differences are an important factor in PGN toxicity

Central and local (enteric) action of orexins

Similarly, elucidating the impact of bias differences between GLP1 and exendin4 in vivo would be challenging due to their quite different pharmacokinetics

Hernandez, K