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Notably, the brain had the lowest reduction in Gclc mRNA abundance (Fig

while this mechanism has been characterized in neuronal contexts, its potential role in regulating cardiomyocyte gene expression via gut-derived dopamine represents a compelling hypothesis that warrants further investigation

Gong et al., 2023)

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In the central nervous system, they act on appetite-regulating centers in the hypothalamus, reducing hunger and increasing satiety signals