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Brand-name GLP-1s (Wegovy, Zepbound, Foundayo, Ozempic, Mounjaro) are FDA-approved as finished drug products, with full clinical trial data and post-market surveillance

In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

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In fact, a shortage of such a vital medication like Ozempic can increase the incidence of hospitalizations and, regrettably, mortality rates, as indicated in a review by the American Journal of Therapeutics

Genomic DNA from buffy coats (used as matching germline DNA) was extracted using the DNeasy blood and tissue kit (Qiagen)