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Patients should be advised: Call 999 immediately for chest pain, sudden severe headache, difficulty speaking, facial drooping, arm weakness, or other signs of stroke or heart attack Call NHS 111 for urgent non-emergency advice about new or worsening cardiovascular symptoms, including persistent palpitations or unexplained dizziness Conversely, if blood pressure does not improve as expected with weight loss or worsens this should prompt reassessment of the overall cardiovascular risk profile and consideration of additional investigations

The Hierarchy Principle in Practice Lower tiers must be solid before higher tiers matter

Mounjaro and Weight Loss: What to Know Though Mounjaro is FDA-approved for type 2 diabetes and not for weight loss, patients may still question its potential weight management benefits

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Patients should maintain adequate hydration, particularly during the initial weeks of treatment when gastrointestinal effects are most pronounced