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It was developed specifically as a selective secretagogue, designed to trigger GH release while avoiding the hormonal "noise" (cortisol, prolactin) seen with earlier GHRPs

Thus, leucine-973 in the juxtamembrane region of the IR acts as a crucial residue differentiating IR signaling from IGF1R signaling

Os autores ressaltam, porm, que os achados ainda so preliminares e dependem de novos estudos clnicos em humanos

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