glp-1 medication pregnancy safety How safe are GLP-1R agonists in early pregnancy? GLP-1/GIP: Contraception and Pregnancy Safety

These medications work by mimicking naturally occurring hormones that regulate appetite and blood sugar

doi: 10.1002/rcm.9731 38 NanjiA

Gunenc AN, Graf B, Stark H, Chari A

Strategies for managing plateaus include: Verify medication adherence and proper injection technique Reassess dietary intake, as reduced appetite may normalize over time Increase structured physical activity with emphasis on resistance training Consider dose optimization if the patient is not yet at the maximum approved dose Evaluate for addition of a complementary medication (phentermine, naltrexone/bupropion, or topiramate) Reframe expectations: weight maintenance at a lower body weight is itself a significant clinical success Clinical Training and Certification The complexity of prescribing incretin-based medications for obesity demands formal clinical education beyond what most providers receive in residency or advanced practice training

10.1083/jcb.201701136 J

By addressing underlying metabolic factors, treatment may help improve energy levels and overall metabolic function