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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

doi: 10.1200/JCO.2024.42.16_suppl.1003

Schmid-Grendelmeier, P

Endoplasmic reticulum stress and oxidative stress The accumulation of lipotoxic speciesincluding free fatty acids (FFAs), diacylglycerols, phospholipids, and free cholesteroltriggers endoplasmic reticulum (ER) stress, leading to activation of multiple cellular stress pathways

By contrast, in EGFR-TKI resistance, only a correlation between PSAT1 downregulation and reversed resistance has been established

Interestingly, the primary anti-ferroptotic function of LDHB is associated with the anti-ferroptotic function of CoQH2 and thus acts in parallel with the mitochondrial enzyme DHODH and also with the GPX4-dependent defense mechanism