Factors like dose level, speed of dose escalation, baseline fitness, and genetics influence whether tiredness appears and how long it lasts
( A ) Plasma TG and AUC over 180 minutes in 25- to 30-week-old mice fed a regular chow (RC) diet during a lipid tolerance test (LTT) in response to water or a systemic dose of sitagliptin (10 mg/kg) ( n = 16/group)
While a high-fat diet increases cholesterol secretion into the bile, which can lead to sludge and stone formation, 9 rapid weight loss and less frequent, low-fat meals also contribute to sludge and stone formation, as discussed later
Sources & Further Reading 2
The interesting part was that urinary uric acid excretion didn't change much
Blocking FSH induces thermogenic adipose tissue and reduces body fat