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The pain can be so severe that patients avoid bowel movements and become constipated (proctogenic constipation), which worsens the situation

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doi: 10.1016/j.jsbmb.2021.105823 78 MushtaqFAkhtarMFSaleemASharifAAkhtarBAskaryAEet al

Coverage varies by payer, and documentation must explain why assistance was medically necessary

This kind of enteric-triggered release protects acid-labile compounds through the stomach and targets their release to intestinal absorption sites