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As demonstrated in Figure 3, PCPA significantly decreased plasma 5-HT levels in wild type mice, which was accompanied by elevations in AST, ALT levels and liver necrosis and the reduction of 5-day's survival

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Therefore, elevated GGT expression increases tumor cell resistance to ferroptosis, safeguarding cells from ROS and lipid peroxidation, thus driving tumor cell proliferation, metastasis and chemotherapy drug resistance (85,107)

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