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These findings reinforce the role of IGF-1 in glucose homeostasis

While they may reduce pigmentation, overuse or unsupervised application can damage the skin

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High circulating IGF-1 levels have been positively correlated with bad prognosis in patients undergoing endocrine therapy [28], while another study found that high serum IGF-1 is associated with increased all-cause mortality in a cohort of women with established breast malignancy [29]

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The process mostly starts much earlier, inside the immune system and the gut