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A further theory relates to the ability of UA to form complexes with metal ions such as Fe(III) 6

In children, vitamin D deficiency can cause rickets, a disease which results in bone deformations

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Considering the complexity of crosstalk between signaling pathways, an unknown p70S6K independent mechanism might exist to promote cell survival, which is inhibited by the combination of IGF-1R and MEK1/2 inhibitors