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How Wegovy and Phentermine Work Differently To understand why someone might consider combining these two medications, it is helpful to look at how they function individually
Despite the negative effects of exenatide on bone fracture risk found in the above meta-analysis, a study of 69 metformin-treated subjects with T2D randomized to exenatide twice-daily (n = 36) or insulin glargine once-daily (n = 33) showed that bone mineral density was similar in both groups after the 44-week therapy (between-group difference p = 0.782)
This is because, in comparison to GLP-1, semaglutide has two amino acid substitutions, which makes it less vulnerable to degradation by the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) [97] and gives it the distinct advantage of increased albumin affinity [96]
Conclusion arGLP-1 are effective and safe for managing IWL or WR after BS, leading to significant weight loss, comorbidity improvement, and sustained %TWL
Improves insulin sensitivity and cardiovascular markers
Contraindications will likely include a history of medullary thyroid cancer or MEN 2 syndrome, and pregnancy
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