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[38] In Xiaflex-treated 9 patients (0.9%), a combination of penile ecchymosis or hematoma, sudden penile detumescence, and/or a penile popping sound or sensation was reported, and in these cases, a diagnosis of corporal rupture could not be excluded

This may be plausible given the interspersed heterologous contact between alfa- and beta-cells in the pancreas of primates (89, 90), and the possibility that beta-cells may have cytoplasmic extensions that span alfa-cells (89)

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If any side effects occur, they are typically mild and resolve quickly