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There is no evidence of fibrotic accumulation in any of these patients after PGE injections

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A review of the anti-cancer, radioprotective and anti-inflammatory effects of turmeric sourced compounds, Frontiers in Nutrition (2024) Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials, ACS Pharmacology & Translational Science (2023) Curcumin combination chemotherapy: The implication and efficacy in cancer, Molecules (2019) Impact of curcumin (with or without piperine) on the pharmacokinetics of tamoxifen, Cancers (2019) Benefits of curcumin in the vasculature: A therapeutic candidate for vascular remodeling in arterial hypertension and pulmonary arterial hypertension?, Frontiers in Physiology (2022) Effect of co-administration of curcumin with amlodipine in hypertension, Nutrients (2021) Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism, Pharmaceutical Biology (2020) Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with curcuma longa and lepidium sativum, Pharmaceuticals (2022) Pharmacokinetic interactions of curcuminoids with conventional drugs: A review, Journal of Ethnopharmacology (2017) Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical study, Clinical Neuropharmacology (2013) Serotonergic medications, herbal supplements, and perioperative serotonin syndrome, Canadian Journal of Anesthesia (2017) Efficacy and safety of curcumin and curcuma longa extract in the treatment of arthritis: A systematic review and meta-analysis of randomized controlled trial, Frontiers in Immunology (2021) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

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Supplementary Table 2 lists all plasmids and primers used

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