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Sci Technol Food Ind 42(17):9499 Rakestraw JA, Sazinsky S, Piatesi A, Antipov E, Wittrup KD (2009) Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae

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A phase I/II trial (NCT04971733) aims to assess the safety, tolerability, and target engagement of E2814 ( 23 ) in participants with dominantly inherited AD (DIAD), with completion expected in 2025

The effects are small on average