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In the STEP and SURMOUNT trial programs, participants treated with semaglutide and tirzepatide respectively achieved average weight reductions of 15 to 22% of total body weight, losses that had previously been achievable only through bariatric surgery [8,9]

Second, better metabolic health matters for bone quality, not just bone quantity. What this new research means for you This is an interesting and potentially important piece of research, but it should not be interpreted as evidence that semaglutide should now be prescribed specifically to prevent fractures or treat osteoporosis, cautions Dr