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A fetuss face and brain develop around the same time, which led to the hypothesis that differences in facial features could reflect differences in brain development
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Vitamin B12 absorption occurs primarily in the terminal ileum through intrinsic factor-mediated absorption (for both dietary and supplemental B12) and passive diffusion (particularly relevant for high-dose supplements)
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As with the skin work, the framing in published reviews remains observational with respect to mechanism, and most authors note that the in vivo translation outside of topical and injected animal-model contexts is not fully characterized
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