Tienen advertencias importantes, incluyendo riesgo de tumores tiroideos de clulas C (contraindicados en personas con historia personal/familiar de carcinoma medular de tiroides o sndrome MEN2), pancreatitis, y complicaciones de la vescula biliar
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Compared with HFD rats, simvastatin could intervention resulted in a significant decrease in LDL-C levels and a significant increase in total BAs excretion, which led to the promotion of cholesterol consumption in rats that were not fed an HFD