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An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1)

In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

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Concomitant use with coumarin anticoagulants such as warfarin has been associated with elevations in the international normalized ratio, requiring closer INR surveillance and potential dose adjustment