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The theory of excessive opioid peptides The theory of opioid system overload by exogenous foodderived peptides in individuals with ASD or schizophrenia postulates that deficiency of the enzyme DPPIV and/or other proteases that cleave the amino acid proline bond leads to excessive production of opioid peptides derived from gluten and casein in the intestinal lumen

Jun 29 2021;11(1):13521

doi:10.2147/ijwh.S165474

In this context, exercise could also increase the NAD + level and SIRT1 activity due to an increase in NAMPT