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"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044

Compound 5 (1 g, 0.59 mmol) was dissolved in DCM (2.6 mL) under nitrogen atmosphere and ice bath conditions

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Patch testing is important because everyones skin response to new ingredients can vary, and understanding your skins unique needs and your skin's health helps ensure safe and effective use

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