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High glucose and fat also enhance ferroptosis in osteocytes, which can be attenuated through activation of the Nrf2/HO-1 pathway (54)

Several lines of evidence demonstrate that calcitriol exerts immunomodulatory and anti-proliferative effects and these effects have been hypothesized to demonstrate a role for calcitriol as a potential preventative or therapeutic in chronic auto-immune conditions such as type 1 diabetes

Rixen S, Havemeyer A, Tyl-Bielicka A, Pysniak K, Gajewska M, Kulecka M, Ostrowski J, Mikula M, Clement B

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Oxidative damage to DNA in patients with cystic fibrosis

Biotin Biotin (vitamin B 7 ) is required as a cofactor for carboxylase enzymes that are important in the metabolism of fatty acids and amino acids