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(7) Ipamorelin Peptide Potential on Muscle Cell Anabolism Beyond pituitary somatotrophs, Ipamorelin is also posited to act on GHS-R1a expressed in other neural circuits, including populations involved in energy balance and hunger hormone signaling

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Several small observational studies and animal models suggest GLP-1 receptor activation in the hypothalamus may reduce CRH release, the upstream trigger for cortisol production