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This differs from sterile water, which contains no preservative and is generally intended for single-use applications

It also reports limited data in pregnant women and describes embryofetal mortality, structural abnormalities and growth alterations in animal studies, concluding it should be used during pregnancy only if the potential benefit justifies the potential risk

While some of this variation in results is likely attributable to the inherent variability of results between trials, some variation may be attributable to the slight differences in the patient populations between trials, where patients receiving tirzepatide in SURMOUNT-5 had a higher average waist circumference and body weight at baseline (mean [standard deviation (SD)] waist circumference 117.7 [16.1]

The experts believe that the complementary rather than synergistic mechanisms of action make it unlikely that the well-known class effects of GLP1-RAs and SGLT2is will differ in combination

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