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In addition, since iron is heterogeneously distributed across brain regions and cell types (Levi et al., 2024), potential off-target chelation could result in iron depletion in brain regions where iron supports physiological function and consequently affect neuronal and glial metabolism, neurotransmitter synthesis, or cell signaling

The degree of expression of the effects of various cellular pathways is mediated by the structure, functions of individual co-chaperones and their interaction with HSP70

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