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and Aoi, W

Based on the striking phenotypic similarity of TBC1D9B loss to the KO of TMEM55B , we hypothesize that the lysosomal membrane protein TMEM55B serves as a recruitment factor and/ or as an activator of TBC1D9B activity

Moreover, astrocytes in AD often exhibit impaired phagocytic capacity and defective immune clearance, resulting in the accumulation of neuronal debris and secondary iron release, further exacerbating local cytotoxicity and iron dyshomeostasis (Zeng et al., 2025)

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Anti-oxidants such as coenzyme Q10, melatonin, and nicotinamide have been shown to mitigate oxidative stress, enhance mitochondrial function, reduce apoptosis, and im-prove the quality of oocytes and the success rates of ovarian tissue cryopreservation

Steady state (Weeks 38): Continue the same daily dose