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In cellular and animal models, MOTS-c indeed appears to promote bone-forming activity

Biometals 25 , 677686 (2012)

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Searches were performed against a database including the sequences of DDB1, DDA1, DET1, COP1, Ube2e2 and c-Jun

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While in women, melasma is often linked to hormonal fluctuations during events like pregnancy or hormone therapy, men are more likely to develop it due to prolonged sun exposure or occupational factors