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V., Astarita, G., Schwartz, G., Li, X

Key points: Weight loss of at least 3%-5% is beneficial but challenging for many patients to achieve and maintain Patients should be encouraged to minimize consumption of processed and fructose-containing foods A diet low in carbohydrates and saturated fats, with intake of fiber and unsaturated fats, should be instituted with dietician assistance to ensure practical implementation Pharmaceutical therapeutic options Initial options for MASLD were limited and several novel agents studied in clinical trials over the past decade produced disappointing results

However, these animal findings are concerning enough that drug manufacturers and regulatory agencies have recommended caution until we have better human data

Conserved T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

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They work by imitating the behavior of the GLP-1 hormone, which is released in the gut after eating and triggers the body to produce insulin