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SUSTAIN-6, conducted in patients with type 2 diabetes, showed a 26% reduction in major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) with semaglutide compared to placebo

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Although GLP-1R agonists exhibit protective and regulatory effects on blood glucose levels, they have been positively correlated with tumor progression in patients with diabetes [51, 73]

Mutations in this receptor are associated with certain forms of type 2 diabetes

1,2 It usually appears during dose increases and improves with continued treatment