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In the liver, VDR evolutionarily behaves as a nutrient sensor, wherein its impairment mimics a starvation-like state, leading to an increase in adiposity without diet changes (89)

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Despite propensity-score matching and two complementary post-PSM analyses (a diabetes-severity model and an active-comparator design), platform constraints on the number of covariates and unmeasured factors mean that residual biasincluding potential immortal-time/time-origin biascannot be entirely excluded

doi: 10.1093/brain/116.4.811 57 de GrootMJHoeksmaMBlauNReijngoudDJvan SpronsenFJ

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