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Numerous clinical and experimental investigations indicate a strong correlation between GN-induced ARF and oxidative stress 62,63

TGF-1 induced EMT increases the intracellular levels of unstable iron and ROS, and the elevated iron content and oxidative stress in cells undergoing EMT make them more susceptible to ferroptosis

10.1159/000358904 44 GirniusS.CersonskyN.GesellL.CicoS.BarrettW

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Sequential Administration Models: In various pharmacological research areas (e.g., oncology, infectious diseases), sequential administration of different drugs is a common strategy