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Our data suggest that choline can promote liver health by maintaining cholesterol homeostasis.10 Choline induces glucose and insulin intolerance in Pemt(-/-) mice through modulating plasma glucagon and its action in liver.11 Choline supplementation decreased the concentration of liver triacylglycerol during the first 4 wk after parturition

What this means in practice for the optimization-focused research community: triple agonism appears to add a distinct energy expenditure component on top of the appetite suppression and enhanced insulin signaling already established by dual agonism

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