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Onco Targets Ther (2017) 10:562131

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Since LTP and LTD (long-term depression) rely on the influx of Ca 2+ through NMDA channels, metaplasticity may be due to changes in NMDA receptors, altered calcium buffering, altered states of kinases or phosphatases and a priming of protein synthesis machinery

There are substantial variations in the degree of melanin pigmentation between persons of different racial/ethnic groups and between persons of the same racial/ethnic group, and these variations are normal[2, 8, 9]