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Over time, mutated mtDNA molecules can undergo clonal expansion, and once the mutational burden exceeds a critical thresholdtypically 60% and 90% they produce a biochemical defect in OXPHOS, a concept referred to as the mtDNA mutational load (112)

A study reported that supplementation with vitamin E alone for 8 weeks significantly decreased serum triglyceride

Add in the potential for GI side effects that deplete fluids, and dehydration becomes a real risk during retatrutide protocols

This is a game-changer for metabolic health, as research shows that this process can increase NAD+ levels in fat cells, supporting more efficient energy use and fat oxidation