Aripiprazole was administered for 2 years in the diet at doses of 1, 3, 10, and 30 mg/kg/day to ICR mice and 1, 3, and 10 mg/kg/day to F344 rats (0.2 to 5 times and 0.3 to 3 times the maximum recommended human dose [MRHD] based on mg/m2, respectively)
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Schedule: Daily or every-other-day subcutaneous injections for 48 weeks
They are not medications, nor are they intended to diagnose, treat, prevent, or cure any disease or medical condition
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Upregulated expression of proinflammatory genes was also detected in LPS-stimulated BV-2 cells