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Developing cell-type-specific SIRT1 regulatorsfor example, hepatocyte-targeted molecules using GalNAc ligands or KC-specific nanoparticlesmay allow targeted activation, while selective inhibition in cells such as activated HSCs could also be explored

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Arjinajarn P, Pongchaidecha A, Chueakula N, Jaikumkao K, Chatsudthipong V, Mahatheeranont S, et al

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M., Gordon, A