And contrary to some fears that GLP-1 medications might increase the risk of depression and suicidality, as other weight loss drugs have in the past, this study found that these newer medications were linked to a lower risk of suicidal ideation, suicide attempts, and the intention to self-harm
Insulin and insulin resistance
There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)
This tiredness often occurs as your body adjusts to taking in significantly fewer calories
You dont need to worry about timing with meals or other medications
However, when the experiments were done with GLP-1, blood glucose was reduced [22]