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( E ) Mean GSH levels in A549shNRF2-BIND-luc, -BIND-WT NRF2, -BIND-Neh4/5mut cells treated with water (control) or 2.5 ng/mL dox for 48 h

Despite some reports suggesting its influence on testosterone, these are generally considered weak, pointing to more indirect effects that may impact testosterone downstream

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10.1016/j.chembiol.2020.02.005 76 LiuP.ChenW.KangY.WangC.WangX.LiuW.et al (2023)

While low-dose paraxanthine showed a trend toward improvement in older animals, it didn't reach statistical significance (p = 0.07)

Phase II detoxification Conjugates with reactive metabolites (acetaminophen toxin, heavy metals) for excretion via the liver - a primary detox pathway