Discussion SURPASS-6 showed that, in comparison with basal-bolus insulin therapy, treatment with tirzepatide as an add on to basal insulin in adults with long-standing T2D provided superior and clinically meaningful glycaemic control and had the additional benefits of reducing body weight and being associated with substantially less hypoglycaemia and insulin use [39]
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Structural variations can lead to fluctuations in receptor binding affinity, potentially resulting in reduced efficacy, abnormally enhanced effects, or even entirely novel unexpected pharmacological actions
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