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TRPV1 (Transient Receptor Potential channels) and TRPA1 ion channels on sensory nerve endings are upregulated, meaning that chemical stimuli that would be imperceptible on healthy skin trigger pain signaling and neurogenic inflammation in rosacea skin

J Biol Chem (2004) 279(22):2315865.10.1074/jbc.M314322200 202 SayinSIWahlstrmAFelinJJnttiSMarschallHUBambergKet alGut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

That raises the possibility that their effects go beyond just metabolism and could be useful for treating various central nervous system disorders

Metabolism and In Vitro Wound-Closure Assays A 2024 study quantified TB-500 and metabolites in laboratory systems and rats

10.1038/s41388-018-0531-6 91 WeinbergS

Participation of the Mef2c transcription factor