L-glutathione and glutathione are different expressions of the same substance, and there is no essential difference between the two, but their specific efficacy largely depends on whether it is in a reduced state
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Freshly made solutions of equal volume 5,5-dithio-bis(2-nitrobenzoic acid) and glutathione reductase with concentrations of 0.33 g l 1 and 1.67 units per ml, respectively, were mixed with lysate to a final volume of 140 l
An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]
At this point it cannot be ruled out that some of the proteins that were captured with monothiol glutaredoxin mutants as Grx(SSR) species might have just accumulated as unspecific dead-end products