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Each adjustment occurs every 4 weeks based on individual tolerance

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MARKET--MARCH 2000 Increases tissue insulin sensitivity decreased insulin resistance decreased insulinemia reduced fasting and postprandial hyperglycemia in Type II diabetics (non-insulin dependent diabetics, NIDDM) Rosiglitazone* (Avandia)-- FDA approved for management of Type II diabetes ---Concern about this agent responsible for excessive number of heart attack and congestive heart failure (2/2010) Approval as monotherapy or in combination with metformin (Glucophage) might be used with insulin or a sulfonylurea Apparently as effective does troglitazone (Rezulin) in controlling blood glucose without liver toxicity Long-term safety/benefits of rosiglitazone (Avandia) in patients with Type II diabetes: yet to be determined

AOD-9604 Research Applications & Key Findings Metabolic and Obesity Research Weight Loss and Fat Reduction Studies Initial clinical trials in obese adults showed promising results, though later studies revealed limitations

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