GI symptoms GI symptoms, the most frequently reported adverse effect, results from semaglutides delayed gastric emptying (the drugs action on appetite regulation)
In healthy adults, CJC-1295 produced sustained increases in GH (2- to 10-fold) and IGF-1 (1.5- to 3-fold) lasting days per dose[1]
Parts of Mounjaro (tirzepatide) Injection Supplies needed to give your injection Mounjaro (tirzepatide) Injection Compatible needle Swab Gauze or cotton ball Sharps disposal container or household container Preparing to inject Mounjaro (tirzepatide) Step 1: Wash your hands with soap and water
For people living with obesity and MASH, at present, the authors recommend the use of tirzepatide as first line treatment, but note the Phase III ESSENCE trial, not included in the present algorithm because it was published after January, 2025, showed that semaglutide was associated with a significant improvement in MASH and liver fibrosis similar to tirzepatide
Biomed Pharmacother 153:113430
However, its GLP-1-based mechanism of action could theoretically increase the risk of certain cancers [15]
