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qPCR analysis confirmed that Rf regulates critical genes, including ANXA2, BAZ1A, DNMT3L, and MMP9, thereby clarifying its underlying mechanism of action
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Important in this context is the recent development of drug, a small TAT-TrkB peptide, that prevented TrkB-FL cleavage, improved cognitive performance, ameliorated synaptic plasticity deficits and prevented Tau pathology progression in vivo in a mouse model of AD [233]
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