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Abhijit Basu A, Dvorina N, Baldwin W, Mazumder B

Its extreme short half-life (minutes) means intranasal or oral routes without modification are ineffective due to rapid degradation

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Increasing GSH through synthesis would also seem to be useful therapeutically but as oxidants and most electrophiles would not seem appropriate, natural compounds such as curcumin, a principal ingredient of curry powder (Dickinson et al., 2003), and sulforaphane, a potent Phase II gene-inducing compound in broccoli, (Brooks et al., 2001) have been proposed but none of these natural has actually become a major therapeutic agent