Nutrition 18 , 217221 (2002)
GLP-1 (semaglutide or tirzepatide) Therapy in Older Adults: Balancing Benefit & Risk Beyond Age 65 Joshua Silva, MD Dec 12, 2025 4 min read Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Many discussions about GLP-1 medications in older adults come from friends, family, or acquaintances , as well as online forums, news stories, and social media posts
NNMT metabolizes nicotinamide into 1-methylnicotinamide (MNA), diverting it away from the NAD+ salvage pathway
Your reason for use is especially important
Gastrointestinal Effects Dominate This Category Nearly half of GLP-1 users experience nausea, and about a quarter deal with vomiting or constipation
Focus on manufacturing oversight, quality assurance, dosing consistency, and available clinical evidence rather than assigning blame